dual specificity protein phosphatase 4 (MAP kinase phosphatase 2, dual-specificity phosphatase hVH-2, DUSP4, MKP2, VH2)

Function

• regulates mitogenic signal transduction by dephosphorylating both Thr & Tyr on MAP kinases ERK1 & ERK2

protein tyrosine phosphate + H2O
                  <-->
protein tyrosine + phosphate

phosphoprotein + H2O <--> protein + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 rhodanese domain
• contains 1 tyrosine-protein phosphatase domain

Compartment

nucleus

More general terms

• dual specificity phosphatase
• mitogen activated protein kinase phosphatase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1846
• OMIM: https://mirror.omim.org/entry/602747
• UniProt: http://www.uniprot.org/uniprot/Q13115.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1846