dual specificity protein phosphatase 13 (testis- & skeletal-muscle-specific DSP, dual specificity phosphatase SKRP4, DUSP13, TMDP)

Function

• may be involved in the regulation of meiosis &/or differentiation of testicular germ cells during spermatogenesis
• exhibits intrinsic phosphatase activity towards both phospho- Ser/Thr & Tyr of myelin basic protein, with similar specific activities in vitro

protein tyrosine phosphate + H2O
                 <-->
protein tyrosine + phosphate

phosphoprotein + H2O <--> a protein + phosphate

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class dual specificity subfamily
• contains 1 tyrosine-protein phosphatase domain

Expression

most abundantly expressed in the testis

More general terms

• dual specificity phosphatase

More specific terms

• dual specificity protein phosphatase 13 isoform MDSP; branching-enzyme interacting DSP; muscle-restricted DSP (DUSP13, BEDP, MDSP)

Database

• UniProt: http://www.uniprot.org/uniprot/Q9UII6.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=51207