protein tyrosine phosphatase 18, non-receptor type; brain-derived phosphatase (PTPN18, BDP1)

Function

• differentially dephosphorylates autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues
• interacts with PSTPIP1 (putative)

Structure

• belongs to the protein-tyrosine phosphatase family non-receptor class 4 subfamily
• contains 1 tyrosine-protein phosphatase domain

Compartment

nucleus (putative), cytoplasm

Expression

• expressed in brain, colon & several tumor-derived cell lines

More general terms

• tyrosine phosphatase, non-receptor type

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2646
• OMIM: https://mirror.omim.org/entry/606587
• UniProt: http://www.uniprot.org/uniprot/Q99952.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=26469