protein phosphatase-2C delta; protein phosphatase 1D; protein phosphatase Mg+2-dependent 1 delta; PP2C-delta; p53-induced protein phosphatase 1 ( PPM1D, WIP1)

Function

• required for the relief of p53-dependent checkpoint mediated cell cycle arrest
• binds to & dephosphorylates Ser-15 of TP53 & Ser-345 of CHEK1 which contributes to the functional inactivation of these proteins
• interacts with CHEK1

Cofactor: binds 2 Mg+2 or Mn+2 per subunit

Structure

• belongs to the PP2C family
• contains 1 PP2C-like domain

Expression

induced by p53

More general terms

• protein phosphatase-2C

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:8493
• OMIM: https://mirror.omim.org/entry/605100
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=8493