cytosolic phospholipase A2 zeta (cPLA2-zeta, phospholipase A2 group IVF, PLA2G4F)

Function

• Ca+2-dependent phospholipase A2
• selectively hydrolyzes glycerophospholipids in the sn-2 position
• higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine
• stimulated by cytosolic Ca+2

Structure

• contains 1 C2 domain
  • N-terminal C2 domain associates with lipid membranes & mediates its regulation by presenting the active site to substrate in response to elevations of cytosolic Ca+2
• contains 1 PLA2c domain

Compartment

• cytoplasm
• Ca+2-dependent translocation to lysosomal membranes

Alternative splicing

named isoforms=3

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)

Database

• UniProt: http://www.uniprot.org/uniprot/Q68DD2.html