cytosolic phospholipase A2 epsilon (cPLA2-epsilon, phospholipase A2 group IVE, PLA2G4E)

Function

• Ca+2-dependent phospholipase A2
• selectively hydrolyzes glycerophospholipids in the sn-2 position
• stimulated by cytosolic Ca+2

phosphatidylcholine + H2O
          <-->
1-acylglycerophosphocholine + carboxylate

Structure

• contains 1 C2 domain
  • N-terminal C2 domain associates with lipid membranes & regulates active site interaction with substrate in response to elevations of cytosolic Ca+2
• contains 1 PLA2c domain

Compartment

• tcytoplasm
• translocates to lysosomal membranes (Ca+2-dependent)

Alternative splicing

named isoforms=2

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)

Database

• UniProt: http://www.uniprot.org/uniprot/Q3MJ16.html