platelet-activating factor acetylhydrolase 2, cytoplasmic; serine-dependent phospholipase A2; SD-PLA2; hSD-PLA2 (PAFAH2)

Function

• marked selectivity for phospholipids with short acyl chains at the sn-2 position
• may share a common physiologic function with the plasma-type enzyme

1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate

Inhibition:

• inhibited by phenylmethanesulfonyl fluoride, 3,4,dichloroisocoumarin, diisopropyl fluorophosphate (DFP) & diethyl p-nitrophenyl phosphate (DENP)

Structure

• monomer
• belongs to the serine esterase family

Compartment

cytoplasm

Expression

• broadly expressed
• high;y expressed in B-lymphocytes & T-lymphocytes
• in brain, expression is restricted to amygdala & frontal cortex

More general terms

• phospholipase A2; phosphatidylcholine 2-acylhydrolase (PLA2)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5051
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5051
• OMIM: https://mirror.omim.org/entry/602344
• UniProt: http://www.uniprot.org/uniprot/Q99487.html