cathepsin-L2 (cathepsin U, cathepsin V, CTSL2, CATL2, CTSU, CTSV, UNQ268/PRO305)

Function

• cysteine protease
• role in corneal physiology
• recombinant enzyme hydrolyzes proteins (serum albumin, collagen) & synthetic substrates (Z-Phe-Arg-NHMec > Z-Leu-Arg-NHMec > Z-Val-Arg-NHMec)

Structure

belongs to the peptidase C1 family

Compartment

lysosome (putative)

Expression

• predominantly expressed in the thymus & testis
• also expressed in corneal epithelium > conjuctival epithelium & skin

More general terms

• cysteine proteinase; thiol proteinase
• cathepsin

Additional terms

• cathepsin-L1 (major excreted protein, MEP, CTSL, CTSL1)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1515
• OMIM: https://mirror.omim.org/entry/603308
• UniProt: http://www.uniprot.org/uniprot/O60911.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1515