serine protease HTRA1; high-temperature requirement A serine peptidase 1; L56; serine protease 11 (HTRA1, HTRA, PRSS11)

Function

• serine protease
• may regulate availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins
• represses signaling by TGF-beta family members

Structure

• belongs to the peptidase S1B family
• contains 1 IGFBP N-terminal domain
• contains 1 Kazal-like domain
• contains 1 PDZ domain (DHR domain)

Compartment

secreted

Expression

• expressed in a variety of tissues
• strongest expression in placenta

Pathology

• polymorphism in the promoter region of HTRA1 are the cause of susceptibility to age-related macular degeneration type 7 (ARMD7)
• defects in HTRA1 are the cause of CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts & leukoencephalopathy

More general terms

• serine protease
• secreted protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5654
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5654
• OMIM: https://mirror.omim.org/entry/600142
• OMIM: https://mirror.omim.org/entry/602194
• OMIM: https://mirror.omim.org/entry/610149
• UniProt: http://www.uniprot.org/uniprot/Q92743.html