bradykinin B2 receptor; BK-2 receptor; B2R (BDKRB2 BKR2)
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Function
- receptor for bradykinin
- associated with G proteins that activate phosphatidylinositol-Ca+2 second messenger system
Structure
belongs to the G-protein coupled receptor 1 family
Compartment
Alternative splicing
named isoforms=2
Expression
- ubiquitous
- widespread in normal smooth muscle tissue & neurons
Pharmacology
- icatibant, a specific antagonist of bradykinin B2 receptors, is approved in Europe for treatment of hereditary angioedema
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/P30411.html
- ↑ Wikipedia; Note: bradykinin receptor entry http://en.wikipedia.org/wiki/bradykinin_receptor
- ↑ SeattleSNPs http://pga.gs.washington.edu/data/bdkrb2/
- ↑ Schini et al Bradykinin stimulates the production of cyclic GMP via activation of B2 kinin receptors in cultured porcine aortic endothelial cells. J Pharmacol Exp Ther 1990 Feb;252(2):581-5 PMID: https://www.ncbi.nlm.nih.gov/pubmed/2156053