NO synthase-2C (inducible, NOS2C)

Function

• produces nitric oxide (NO), a messenger molecule with diverse functions throughout the body
• in macrophages, NO mediates tumoricidal & bactericidal actions

L-arginine + n NADPH + m O2
           <-->
citrulline + nitric oxide + n NADP+

Cofactor:

• heme group (putative)
• binds 1 FAD (putative)
• binds 1 FMN (putative)
• tetrahydrobiopterin (BH4)

Structure

belongs to the NOS family

Notes

could be the product of a pseudogene

More general terms

• NO synthase-2 (inducible, i-NOS)

Additional terms

• nitric oxide (NO, endothelium derived relaxation factor {EDRF})

Database

• OMIM: https://mirror.omim.org/entry/600720
• UniProt: http://www.uniprot.org/uniprot/Q14961.html