insulin-regulating transcription factor LMX1; LIM homeobox transcription factor 1-alpha; LIM/homeobox protein 1.1; LMX-1.1; LIM/homeobox protein LMX1A (LMX1A)

Function

• acts as a transcriptional activator by binding to an A/T-rich sequence, the FLAT element, in the insulin gene promoter
• required for development of the roof plate and, in turn, for specification of dorsal cell fates in the CNS & developing vertebrae (putative)

Structure

• contains 1 homeobox DNA-binding domain
• contains 2 LIM Zn+2-binding domains

Compartment

nucleus (putative)

Alternative splicing

named isoforms=2

Expression

• isoform 1 is expressed in many tissues
• not found in heart, liver, spleen & testis
• relatively highly expressed in fetal brain
• isoform LMX1A-4B is expressed in testis

More general terms

• homeobox protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4009
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4009
• OMIM: https://mirror.omim.org/entry/600298
• UniProt: http://www.uniprot.org/uniprot/Q8TE12.html