caudal type homeobox transcription factor 2; homeobox protein CDX-2 (CDX2, CDX3)

Function

• role in transcriptional regulation of multiple genes expressed in the intestinal epithelium
• role in broad range of functions from early differentiation to maintenance of intestinal epithelial lining of both the small & large intestine
• phosphorylation of Ser-60 mediates the transactivation capacity (putative)

Structure

• belongs to the Caudal homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

More general terms

• caudal type homeobox transcription factor (CDX)

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1045
• OMIM: https://mirror.omim.org/entry/600297
• UniProt: http://www.uniprot.org/uniprot/Q99626.html