homeobox protein HOX-D10; HOX-4D; Hox-4E (HOXD10, HOX4D)

Function

• sequence-specific transcription factor
• part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Structure

• belongs to the Abd-B homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• strongly expressed in the adult male & female urogenital tracts
• expressed in the developing limb buds

Pathology

• defects in HOXD10 are a cause of congenital vertical talus

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P28358.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3236
• OMIM: https://mirror.omim.org/entry/142984
• OMIM: https://mirror.omim.org/entry/192950
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3236