homeobox protein HOX-A13; HOX-1J (HOXA13, HOX1J)

Function

• sequence-specific transcription factor
• part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis

Structure

• belongs to the Abd-B homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Pathology

• defects in HOXA13 are the cause
  • hand-foot-genital syndrome
  • Guttmacher syndrome

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P31271.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3209
• OMIM: https://mirror.omim.org/entry/140000
• OMIM: https://mirror.omim.org/entry/142959
• OMIM: https://mirror.omim.org/entry/176305
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3209