homeobox protein-7; HOX-7; homeobox protein MSX-1; Msh homeobox 1-like protein; MSX1 (HOX7)

Function

• acts as a transcriptional repressor
• may play a role in limb-pattern formation
• acts in cranofacial development & specifically in odontogenesis
• expression in the developing nail bed mesenchyme is important for nail plate thickness & integrity

Structure

• belongs to the Msh homeobox family
• contains 1 homeobox DNA-binding domain

Compartment

nucleus

Expression

• expressed in the developing nail bed mesenchyme

Pathology

• defects in MSX1 are a cause of:
  • autosomal dominant hypodontia
  • Witkop syndrome
  • non-syndromic orofacial cleft type 5
• chromosomal aberration involving MSX1 is a cause of Wolf-Hirschhorn syndrome

More general terms

• homeobox protein

Database

• UniProt: http://www.uniprot.org/uniprot/P28360.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4487
• OMIM: https://mirror.omim.org/entry/106600
• OMIM: https://mirror.omim.org/entry/142983
• OMIM: https://mirror.omim.org/entry/189500
• OMIM: https://mirror.omim.org/entry/194190
• OMIM: https://mirror.omim.org/entry/608874