ATP-binding cassette sub-family G member 5; sterolin-1 (ABCG5)

Function

• transporter
• role in selective transport of the dietary cholesterol in & out of enterocytes (putative)
• role in selective sterol excretion by the liver into bile
• may form heterodimers with ABCG8 or be tightly coupled to ABCG8 along a pathway regulating dietery-sterol absorption & excretion

Structure

• belongs to the ABC transporter family, ABCG (White) subfamily
• contains 1 ABC transporter domain

Compartment

membrane

Expression

• strongly expressed in the liver
• lower levels in the small intestine & colon

Pathology

• defects in ABCG5 are a cause of sitosterolemia

More general terms

• transmembrane 6 protein
• ATP-binding cassette sub-family G (ABC transporter-G, ABG)
• glycoprotein
• phosphoprotein

Additional terms

• beta-sitosterolemia; phytosterolemia; shellfish sterolemia

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6424
• OMIM: https://mirror.omim.org/entry/210250
• OMIM: https://mirror.omim.org/entry/605459
• UniProt: http://www.uniprot.org/uniprot/Q9H222.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=64240