heat shock-related 70 kD protein 2; heat shock 70 kD protein 2 (HSPA2)

Function

• in cooperation with other chaperones, Hsp70s stabilize preexistent proteins against aggregation & mediate folding of newly translated polypeptides in the cytosol as well as within organelles
• recognition of nonnative conformations of other proteins
• binds extended peptide segments with a net hydrophobic character exposed by polypeptides during translation & membrane translocation, or following stress-induced damage
• interacts with ZNF541 (putative)

Structure

belongs to the heat shock protein 70 family

More general terms

• heat shock protein [hsp] 70, HSP70A or HSP-A

Database

• UniProt: http://www.uniprot.org/uniprot/P54652.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3306
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3306
• OMIM: https://mirror.omim.org/entry/140560