calpain-11 catalytic [large] subunit (calcium-activated neutral proteinase 11, CAPN11)

Function

• Ca+2-regulated non-lysosomal thiol-protease
• catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling & signal transduction
• broad endopeptidase specificity

Structure

• heterodimer of a large (catalytic) & a small (regulatory) subunit
• belongs to the peptidase C2 family
• contains 1 calpain catalytic domain
• contains 2 EF-hand domains

Expression

highest expression in testis

More general terms

• calpain catalytic or large subunit

Component of

• calpain-11

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1113
• UniProt: http://www.uniprot.org/uniprot/Q9UMQ6.html
• OMIM: https://mirror.omim.org/entry/604822