calpain-10 catalytic subunit (Ca+2-activated neutral proteinase 10, CANP 10, CAPN10, KIAA1845)

Function

• Ca+2-regulated non-lysosomal thiol-protease
• catalyzes limited proteolysis of substrates involved in cytoskeletal remodeling & signal transduction
• broad endopeptidase specificity

Structure

• belongs to the peptidase C2 family
• contains 1 calpain catalytic domain

Alternative splicing

named isoforms=8

Expression

ubiquitous

Pathology

• genetic variations in CAPN10 are associated with susceptibility diabetes mellitus type 2

More general terms

• calpain catalytic or large subunit

Database

• OMIM: https://mirror.omim.org/entry/125853
• OMIM: https://mirror.omim.org/entry/601283
• OMIM: https://mirror.omim.org/entry/605286
• UniProt: http://www.uniprot.org/uniprot/Q9HC96.html