NADH-cytochrome b5 reductase 1 (b5R.1, NAD(P)H:quinone oxidoreductase type 3 polypeptide A2, Humb5R2, CYB5R1, NQO3A2, UNQ3049/PRO9865)

Function

• NADH-cytochrome b5 reductase
• microsomal electron transport system
• desaturation & elongation of fatty acids
• cholesterol biosynthesis
• drug metabolism
• methemoglobin reduction in erythrocytes

NADH + 2 ferricytochrome b5  <-->  NAD+ + 2 ferrocytochrome b5

Cofactor: FAD

Structure

• belongs to the flavoprotein pyridine nucleotide cytochrome reductase family

Compartment

membrane

Expression

widely expressed

More general terms

• NADH cytochrome b5 reductase; NADH-methemoglobin reductase

Database

• OMIM: https://mirror.omim.org/entry/608341
• UniProt: http://www.uniprot.org/uniprot/Q9UHQ9.html