cytochrome P450 2A13 (CYP2A13)

Function

• coumarin 7-hydroxylase activity
• activation of hexamethylphosphoramide
• activation of procarcinogens
  • N,N-dimethylaniline
  • 2'-methoxyacetophenone
  • N-nitrosomethylphenylamine
  • 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone*

* tobacco-specific carcinogen

Compartment

membrane-bound, endoplasmic reticulum

Expression

• expressed in liver & extrahepatic tissues
• expressed in nasal mucosa, lung, trachea, brain, mammary gland, prostate, testis, & uterus
• not expressed in heart, kidney, bone marrow, colon, small intestine, spleen, stomach, thymus,skeletal muscle

Polymorphism

• Cys-257 allele is 37 to 56% less active than the wild-type Arg-257 protein toward all substrates tested frequencies 1 .9% white 14.4% black 5.8% Hispanic 7.7% Asian

More general terms

• cytochrome P450 2A (CYP2A)

Database

• UniProt: http://www.uniprot.org/uniprot/Q16696.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1553
• OMIM: https://mirror.omim.org/entry/608055
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1553