3-hydroxymethyl-3-methylglutaryl-CoA lyase 2 (3-hydroxymethyl-3-methylglutaryl-CoA lyase-like protein 1, HMGCLL1)

Function

• amino-acid degradation; L-leucine degradation
• acetoacetate from 3-isovaleryl-CoA: step 4/4

(S)-3-hydroxy-3-methylglutaryl-CoA <--> acetyl-CoA + acetoacetate

Structure

belongs to the HMG-CoA lyase family

Alternative splicing

named isoforms=3

More general terms

• carboxy-lyase or decarboxylase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5451
• UniProt: http://www.uniprot.org/uniprot/Q8TB92.html