2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase; OHCU decarboxylase; parahox neighbor (PRHOXNB, URAD)
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Function
- catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to S-allantoin
- purine metabolism; uric acid degradation; (S)-allantoin from uric acid: step 3/3
Structure
belongs to the OHCU decarboxylase family
Compartment
Expression
- apparently not expressed
- could be the product of a pseudogene
- in primates, genes coding for enzymes degrading uric acid were inactivated & converted to pseudogenes[2]
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/A6NGE7.html
- ↑ 2.0 2.1 Ramazzina I, Folli C, Secchi A, Berni R, Percudani R. Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. Nat Chem Biol. 2006 Mar;2(3):144-8. Epub 2006 Feb 5. PMID: https://www.ncbi.nlm.nih.gov/pubmed/16462750