histidine decarboxylase (HDC)

Function

• catalyzes decarboxylation of histidine to histamine
• amine & polyamine biosynthesis; histamine biosynthesis
• histamine from L-histidine: step 1/1

Cofactor: pyridoxal phosphate

L-histidine = histamine + CO2

Structure

• homodimer
• belongs to the group II decarboxylase family

More general terms

• carboxy-lyase or decarboxylase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3067
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3067
• OMIM: https://mirror.omim.org/entry/142704
• UniProt: http://www.uniprot.org/uniprot/P19113.html