N-acylglucosamine 2-epimerase; AGE; GlcNAc 2-epimerase; N-acetyl-D-glucosamine 2-epimerase; renin-binding protein; RnBP (RENBP)

Function

• N-acetylneuraminic acid biosynthesis
• catalyzes interconversion of N-acetylglucosamine to N-acetylmannosamine
• binds to renin forming a protein complex called HMW renin & inhibits renin activity

N-acyl-D-glucosamine  <-->  N-acyl-D-mannosamine.

Structure

• homodimer
• belongs to the N-acylglucosamine 2-epimerase family

Alternative splicing

named isoforms=2

Notes

• uncertain whether Met-1 or Met-11 is the initiator

More general terms

• epimerase

Component of

• high molecular weight renin (HMW renin)

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=5973
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:5973
• OMIM: https://mirror.omim.org/entry/312420
• UniProt: http://www.uniprot.org/uniprot/P51606.html