sulfotransferase family cytosolic 1B member 1; ST1B1; sulfotransferase 1B1; sulfotransferase 1B2; ST1B2; thyroid hormone sulfotransferase (SULT1B1, ST1B2, SULT1B2)

Function

• catalyzes the sulfate conjugation of many hormones, neurotransmitters, drugs & xenobiotic compounds
• sulfonation increases the water solubility of most compounds, & thus their renal excretion, but may also result in bioactivation to form active metabolites
• sulfate conjugation of:
  • dopamine, small phenols such as 1-naphthol & p-nitrophenol & thyroid hormones, including 3,3'-diiodothyronine, triidothyronine, reverse triiodothyronine & thyroxine

Structure

• monomer (putative)
• belongs to the sulfotransferase 1 family

Compartment

cytoplasm (putative)

Expression

• highly expressed in the liver, peripheral blood leukocytes, colon (mucosal lining), small intestine (jejunum) & spleen
• lesser expression in lung, placenta & thymus

More general terms

• sulfotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27284
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27284
• OMIM: https://mirror.omim.org/entry/608436
• UniProt: http://www.uniprot.org/uniprot/O43704.html