sulfotransferase 1A1; aryl sulfotransferase 1; phenol sulfotransferase 1; phenol-sulfating phenol sulfotransferase 1; P-PST 1; thermostable phenol sulfotransferase; Ts-PST; HAST1/HAST2; ST1A3 (SULT1A1, STP, STP1, OK/SW-cl88)

Function

• catalyzes sulfate conjugation of catecholamines, phenolic drugs & neurotransmitters
• also responsible for sulfation & activation of minoxidil

3'-phosphoadenylyl sulfate + a phenol
                  <-->
adenosine 3',5'-bisphosphate + an aryl sulfate

Structure

• homodimer
• belongs to the sulfotransferase 1 family

Compartment

cytoplasm

Expression

• liver, lung, adrenal, brain, platelets & skin

Pathology

• mediates metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products, thus may play role in the initiation of carcinogenesis

More general terms

• sulfotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6817
• OMIM: https://mirror.omim.org/entry/171150
• UniProt: http://www.uniprot.org/uniprot/P50225.html