bile salt sulfotransferase; hydroxysteroid sulfotransferase; HST; dehydroepiandrosterone sulfotransferase; DHEA-ST; ST2; ST2A3 (SULT2A1, HST, STD)

Function

• catalyzes sulfation of steroids & bile acids in the liver & adrenal glands

3'-phosphoadenylyl sulfate + glycolithocholate
             <-->
adenosine 3',5'-bisphosphate + glycolithocholate 3-sulfate

3'-phosphoadenylyl sulfate + taurolithocholate
             <-->
adenosine 3',5'-bisphosphate + taurolithocholate sulfate

Structure

• homodimer
• N-terminus is blocked
• belongs to the sulfotransferase 1 family

Compartment

cytoplasm

Expression

• liver, adrenal & at lower level in the kidney
• present in human fetus in higher level in the adrenal than the liver & the kidney

More general terms

• sulfotransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=6822
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:6822
• OMIM: https://mirror.omim.org/entry/125263
• UniProt: http://www.uniprot.org/uniprot/Q06520.html