sialyltransferase 7C; alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase III (SIAT7C, ST6GALNAC3)

Function

• role in the biosynthesis of ganglioside GD1A from GM1B
• transfers CMP-neuAc with an alpha-2,6-linkage to galNAc residue on neuAc-alpha-2,3-gal-beta-1,3-galNAc of glycoproteins & glycolipids
• prefers glycolipids to glycoproteins
• protein modification; protein glycosylation

CMP-N-acetylneuraminate +
alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-(N-acetyl-D- galactosaminyl)-glycoprotein
            <-->
CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-(2,6-alpha- N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein

Structure

belongs to the glycosyltransferase 29 family

Compartment

Golgi membrane

Alternative splicing

named isoforms=2

More general terms

• sialyltransferase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=256435
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2564
• UniProt: http://www.uniprot.org/uniprot/Q8NDV1.html