tRNA 2'-phosphotransferase 1 (EC 2.7.1.160) (TRPT1)

Function

• catalyzes last step of tRNA splicing, transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2''cyclic phosphate (probable)

2'-phospho-[ligated tRNA] + NAD+
             <-->
mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O

Structure

belongs to the kptA/TPT1 family

Alternative splicing

named isoforms=2

Expression

• widely expressed
• weakly or not expressed in lung, spleen, small intestine & peripheral blood leukocytes

More general terms

• phosphotransferase
• splicing factor; snRNP-associated protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q86TN4.html