purine nucleoside phosphorylase; inosine phosphorylase (NP, PNP)

Function

-..........-

purine nucleoside + phosphate
      <-->
purine + alpha-D-ribose 1-phosphate

Structure

• homotrimer
• belongs to the PNP/MTAP phosphorylase family

Pathology

• defects in NP are the cause of nucleoside phosphorylase deficiency

More general terms

• glycosyltransferase
• phosphotransferase

Database

• UniProt: http://www.uniprot.org/uniprot/P00491.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4860
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4860
• OMIM: https://mirror.omim.org/entry/164050