glutathione S-transferase A4-4 (GST alpha 4, glutathione S-transferase A4, GSTA4)

Function

• conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
• high catalytic efficiency with 4-hydroxyalkenals such as 4-hydroxynonenal

RX + glutathione = HX + R-S-glutathione

Structure

• homodimer
• belongs to the GST superfamily, alpha family

Compartment

cytoplasm

Expression

• expressed in brain, placenta & skeletal muscle >> lung & liver

More general terms

• glutathione transferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2941
• OMIM: https://mirror.omim.org/entry/605450
• UniProt: http://www.uniprot.org/uniprot/O15217.html