glutathione S-transferase A3-3 (GST alpha 3, glutathione S-transferase A3, GST class-alpha member 3, GSTA3)

Function

• conjugation of reduced glutathione to a wide number of exogenous & endogenous hydrophobic electrophiles
• catalyzes isomerization reactions that contribute to the biosynthesis of steroid hormones
• catalyzes obligatory double-bond isomerizations of delta(5)-androstene-3,17-dione & delta(5)-pregnene-3,20-dione, precursors to testosterone & progesterone, respectively

RX + glutathione = HX + R-S-glutathione

Structure

• homodimer

belongs to the GST superfamily. alpha family

Compartment

cytoplasm

More general terms

• glutathione transferase

Database

• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:2940
• OMIM: https://mirror.omim.org/entry/605449
• UniProt: http://www.uniprot.org/uniprot/Q16772.html