alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; beta-1,2-N-acetylglucosaminyltransferase II; GlcNAc-T II; GNT-II; mannoside acetylglucosaminyltransferase 2; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II (MGAT2)

Function

• catalyzes an essential step in the conversion of oligo- mannose to complex N-glycans
• protein modification; protein glycosylation

Compartment

• Golgi membrane
• single-pass type 2 membrane protein

Pathology

• defects in MGAT2 are the cause of congenital disorder of glycosylation type 2A

More general terms

• aminotransferase
• glycoprotein
• membrane protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=4247
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:4247
• OMIM: https://mirror.omim.org/entry/212066
• OMIM: https://mirror.omim.org/entry/602616
• UniProt: http://www.uniprot.org/uniprot/Q10469.html