2-acylglycerol O-acyltransferase 2 (monoacylglycerol O-acyltransferase 2, acyl CoA:monoacylglycerol acyltransferase 2, MGAT2, hMGAT2, diacylglycerol acyltransferase 2-like protein 5, diacylglycerol O-acyltransferase candidate 5, hDC5, MOGAT2, DC5, DGAT2L5)

Function

• triacylglycerol synthesis
• catalyzes formation of diacylglycerol from 2-monoacylglycerol & fatty acyl-CoA
• preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0.
• role in absorption of dietary fat in the small intestine by catalyzing resynthesis of triacylglycerol in enterocytes

Acyl-CoA + 2-acylglycerol <--> CoA + diacylglycerol

Cofactor:

• enhanced by phosphatidylcholine, phosphatidylserine & phosphatidic acid

Inhibition:

• inhibited by oleic acid & sphingosine

Kinetic parameters:

• KM=45 uM for sn-1-monooleoylglycerol

Structure

belongs to the diacylglycerol acyltransferase family

Compartment

endoplasmic reticulum membrane

Alternative splicing

named isoforms=3

Expression

• highly expressed in liver, small intestine, colon, stomach, kidney

Pathology

• role in diet-induced obesity (putative)

More general terms

• acyltransferase

Database

• UniProt: http://www.uniprot.org/uniprot/Q3SYC2.html