1-acylglycerophosphocholine O-acyltransferase 1 (lung-type acyl-coa:lysophosphatidylcholine acyltransferase 1, acyltransferase-like 2, phosphonoformate immuno-associated protein 3, AYTL2, LPCAT1, PFAAP3)
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Function
- acetyltransferase
- de novo phospholipid biosynthesis
- mediates convertion of 1-acyl-sn-glycero-3-phosphocholine (LPC) into phosphatidylcholine
- Ca+2-independent activity
- preference for saturated fatty acyl-CoAs, & 1-myristoyl or 1-palmitoyl LPC as acyl donors & acceptors, respectively
- may synthesize phosphatidylcholine in pulmonary surfactant thus a role in respiratory physiology
Acyl-CoA + 1-acyl-sn-glycero-3-phosphocholine <--> CoA + 1,2-diacyl-sn-glycero-3-phosphocholine
Structure
- belongs to 1-acyl-sn-glycerol-3-phosphate acyltransferase family
- contains 2 EF-hand domains
- HXXXXD motif is essential for acyltransferase activity & may constitute binding site for the phosphate moiety of glycerol-3-phosphocholine
- di-lysine motif confers endoplasmic reticulum localization for type 1 membrane proteins
Compartment
- endoplasmic reticulum membrane, Golgi membrane
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q8NF37.html
- ↑ Wikipedia: 1-acylglycerophosphocholine O-acyltransferase http://en.wikipedia.org/wiki/1-acylglycerophosphocholine_O-acyltransferase