N-acetylglucosaminyl transferase-5; alpha-1,3(6)-mannosyl-glycoprotein beta-1,6-N-acetylglucosaminyl transferase; alpha-mannoside beta-1,6-N-acetylglucosaminyl transferase; GLCNAC-T V (MGAT5)
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Function
- catalyzes addition of N-acetylglucosamine in beta 1-6 linkage to the alpha-linked mannose of biantennary N-linked oligosaccharides
- protein modification; protein glycosylation
UDP-N-acetyl-D-glucosamine + 6-(2-(N-acetyl-beta-D-glucosaminyl)- alpha-D-mannosyl)-beta-D-mannosyl-R
<-->
UDP + 6-(2,6-bis(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl)- beta-D-mannosyl-R
Structure
belongs to the glycosyltransferase 18 family
Compartment
Golgi membrane
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q09328.html
- ↑ GDB; Note: Glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/homolog?cat=symbol&symbol=MGAT5
- ↑ Functional Glycomics gateway - GTase alpha-1,6-mannosylglycoprotein 6-beta-N- acetylglucosaminyltransferase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_533