beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III; N-acetylglucosaminyltransferase III; GlcNAc-T III; GNT-III (MGAT3, GGNT3)
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Function
- role in regulation of biosynthesis & biological function of glycoprotein oligosaccharides
- catalyzes addition of N-acetylglucosamine in beta 1-4 linkage to the beta-linked mannose of the trimannosyl core of N-linked sugar chains
- protein modification; protein glycosylation
UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R
<-->
UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R
Structure
belongs to the glycosyltransferase 17 family
Compartment
Golgi membrane
More general terms
References
- ↑ UniProt http://www.uniprot.org/uniprot/Q09327.html
- ↑ GGDB; Note: Glycogene database http://riodb.ibase.aist.go.jp/rcmg/ggdb/homolog?cat=symbol&symbol=MGAT3
- ↑ Functional Glycomics gateway - GTase beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyl- transferase http://www.functionalglycomics.org/glycomics/molecule/jsp/glycoEnzyme/viewGlycoEnzyme.jsp?gbpId=gt_hum_540