heparanase-2 (Hpa2, HPSE2, HPA2)

Function

• endoglycosidase
• cell surface & extracellular matrix-degrading enzyme
• cleaves heparan sulfate proteoglycans (HSPGs) into heparan sulfate side chains & core proteoglycans
• implicated in the extravasation of leukocytes & tumor cells
• contribution to angiogenesis

Structure

belongs to the glycosyl hydrolase 79 family

Compartment

membrane, peripheral membrane

Alternative splicing

named isoforms=4

Expression

• widely expressed
• highest expression in brain, mammary gland, prostate, small intestine, testis & uterus
• found both in normal & cancer tissues

Pathology

• contribution to metastasis & angiogenesis
• considered to be a potential target for anti-cancer therapies

More general terms

• glycosidase (glycoside hydrolase)

Additional terms

• heparanase (heparanase-1; Hpa1; endo-glucoronidase; P1-A-1 platelet antigen [Contains: Heparanase 8 kD subunit; Heparanase 50 kD subunit], HPSE, HEP, HPA, HPA1, HPR1, HPSE1, HSE1)

Database

• UniProt: http://www.uniprot.org/uniprot/Q8WWQ2.html