alcohol dehydrogenase 1C (alcohol dehydrogenase subunit gamma, ADH1C, ADH3)

Function

-..........-

an alcohol + NAD+ <--> an aldehyde or ketone + NADH

Cofactor: binds 2 Zn+2 per subunit

Structure

• belongs to the Zn+2-containing alcohol dehydrogenase family

Compartment

cytoplasm

Expression

• active in intestine & kidney in fetal & early postnatal life
• active in liver throughout adulthood

Polymorphism

• 2 main alleles are known
  • ADH3*1 or gamma-1 has Arg-272/Ile-350
    • associated with a fast rate of ethanol oxidation
  • ADH3*2 or gamma-2 has Gln-272/Val-350
    • associated with a slow rate of ethanol oxidation

More general terms

• protein subunit

Component of

• alcohol dehydrogenase (aldehyde reductase)

Database

• UniProt: http://www.uniprot.org/uniprot/P00326.html
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:126
• OMIM: https://mirror.omim.org/entry/103730
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=126