bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2 (NADP-dependent methylenetetrahydrofolate dehydrogenase 2-like protein, [includes: NAD-dependent methylenetetrahydrofolate dehydrogenase; methenyltetrahydrofolate cyclohydrolase], MTHFD2L)

Function

• one-carbon metabolism; tetrahydrofolate pathway

5,10-methylenetetrahydrofolate + NAD+
                 <--> 5,10-methenyltetrahydrofolate + NADH

5,10-methenyltetrahydrofolate + H2O <--> 10-formyltetrahydrofolate

Cofactor: Mg+2 (putative)

Structure

• belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family

Alternative splicing

named isoforms=3

More general terms

• dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/Q9H903.html