short-chain dehydrogenase/reductase 3; DD83.1; retinal short-chain dehydrogenase/reductase 1; retSDR1 (DHRS3)

Function

• catalyzes reduction of all-trans-retinal to all-trans-retinol in presence of NADPH

Structure

• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

membrane

Alternative splicing

named isoforms=2

Expression

• widely expressed, highest levels in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea, spinal cord > skeletal muscle, intestine, lymph node
• no expression detected in brain
• in retina, expressed in cones but NOT rod outer segments
• induced by retinoic acid

Pathology

• gene located in a region of chromosome 1 which is often deleted in aggressive neuroblastomas

More general terms

• dehydrogenase
• transmembrane 4 protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=9249
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:9249
• OMIM: https://mirror.omim.org/entry/612830
• UniProt: http://www.uniprot.org/uniprot/O75911.html