cytosolic 10-formyltetrahydrofolate dehydrogenase; 10-FTHFDH; FDH; aldehyde dehydrogenase family 1 member L1 (ALDH1L1, FTHFD)
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Function
-..........-
10-formyltetrahydrofolate + NADP+ + H2O . <--> tetrahydrofolate + CO2 + NADPH
Structure
- in the N-terminal section; belongs to the GART family
- in the C-terminal section; belongs to the aldehyde dehydrogenase family, ALDH1L subfamily
- contains 1 acyl carrier domain
Compartment
Expression
- highly expressed in liver, pancreas & kidney