dihydropyrimidine dehydrogenase; DHPDHase; dihydrouracil dehydrogenase; dihydrothymine dehydrogenase (DPD, DPYD)

Function

• pyrimidine base degradation
• catalyzes reduction of uracil & thymine to 5,6-dihydrouracil & 5,6-dihydrothymine
• degradation of chemotherapeutic drug 5-fluorouracil
• amino-acid biosynthesis, beta-alanine biosynthesis

Cofactor: binds 2 FAD, 2 FMN, 2 4Fe-4S clusters

Structure

• homodimer
• belongs to the dihydropyrimidine dehydrogenase family
• contains 3 4Fe-4S ferredoxin-type domains

Compartment

cytoplasm

Expression

• expressed in most tissues
• greatest expression in liver & peripheral blood mononuclear cells

Pathology

• defects in DPYD are the cause of dihydropyrimidine dehydrogenase deficiency

Laboratory

• DPYD gene mutation

More general terms

• dehydrogenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=1806
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:1806
• OMIM: https://mirror.omim.org/entry/274270
• UniProt: http://www.uniprot.org/uniprot/Q12882.html