15-hydroxyprostaglandin dehydrogenase [NAD+]; PGDH; prostaglandin dehydrogenase 1 (HPGD, PGDH1)

Function

• inactivation of prostaglandins

(5Z,13E,15S)-11-alpha,15-dihydroxy-9-oxoprost-5,13-dienoate + NAD+
               <-->
(5Z,13E)-11-alpha-hydroxy-9,15-dioxoprost-5,13-dienoate + NADH

Structure

• homodimer
• belongs to the short-chain dehydrogenases/reductases (SDR) family

Compartment

cytoplasm

Pathology

• defects in HPGD are the cause of:
  • primary hypertrophic osteoarthropathy
  • cranioosteoarthropathy

More general terms

• dehydrogenase

Database

• UniProt: http://www.uniprot.org/uniprot/P15428.html
• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3248
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3248
• OMIM: https://mirror.omim.org/entry/259100
• OMIM: https://mirror.omim.org/entry/601688