hematopoietic prostaglandin D synthase; H-PGDS; GST class-sigma; glutathione S-transferase; glutathione-dependent PGD synthase; glutathione-requiring prostaglandin D synthase; prostaglandin-H2 D-isomerase (HPGDS, GSTS, PGDS, PTGDS2)

Introduction

Supertype dehydrogenase used by analogy to PGF synthase.

Function

• catalyzes conversion of PGH2 to PGD2 (glutathione-dependent)
• role in smooth muscle contraction & relaxation
• inhibits platelet aggregation.
• role in expression of PGD & PDJ in hematopoietic cells.

Expression

• expressed in megakaryocytes, but not platelets
• expressed in placenta

More general terms

• dehydrogenase

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=27306
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:27306
• OMIM: https://mirror.omim.org/entry/602598
• UniProt: http://www.uniprot.org/uniprot/O60760.html