hexokinase-3 (hexokinase type III, HK III, HK3)

Function

• carbohydrate metabolism, hexose metabolism
• allosteric enzyme inhibited by its product Glc-6-P

ATP + D-hexose <--> ADP + D-hexose 6-phosphate

Structure

• monomer
• N- & C-terminal halves of this hexokinase show extensive sequence similarity to each other
• catalytic activity is associated with the C-terminus
• regulatory function is associated with the N-terminus
• belongs to the hexokinase family

Notes

• in vertebrates there are 4 major glucose-phosphorylating isoenzymes, designated hexokinase 1, 2, 3 & 4 (glucokinase)

More general terms

• hexokinase

Database

• OMIM: https://mirror.omim.org/entry/142570
• UniProt: http://www.uniprot.org/uniprot/P52790.html