rhomboid-related protein 2 (RRP2, rhomboid-like protein 2, RHBDL2)

Function

• role in regulated intramembrane proteolysis & the subsequent release of functional polypeptides from their membrane anchors
• known substrate: EFNB3
• cleaves type-1 transmembrane domains using a catalytic triad of Ser, His & Asn contributed by different transmembrane domains

Structure

belongs to the peptidase S54 family

Compartment

membrane

Alternative splicing

named isoforms=2

More general terms

• rhomboid-related protein

Database

• UniProt: http://www.uniprot.org/uniprot/Q9NX52.html