protein jagged-2; Jagged2; HJ2 (JAG2)

Function

• putative notch ligand involved in the mediation of notch signaling
• involved in limb development (putative)

Structure

• contains 1 DSL domain
• contains 16 EGF-like domains
• contains 1 VWFC domain

Compartment

• membrane; single-pass type 1 membrane protein

Alternative splicing

named isoforms=2

Expression

• expressed in heart, placenta & skeletal muscle & to a lesser extent in pancreas
• very low expression in brain, lung, liver & kidney

Pathology

• may be associated with Usher syndrome type IA

More general terms

• jagged protein

Database

• Entrez gene: http://www.ncbi.nlm.nih.gov/sites/entrez?db=gene&cmd=Retrieve&dopt=Graphics&list_uids=3714
• Kegg: http://www.genome.jp/dbget-bin/www_bget?hsa:3714
• OMIM: https://mirror.omim.org/entry/602570
• UniProt: http://www.uniprot.org/uniprot/Q9Y219.html